Giant George Wayne is, appropriately enough, a giant cowboy statue brought to life by evil spirits. He mistakes Ace Lightning for the famous Apache, Geronimo. He first appeared in the videogame as part of Dirty Rat's boss battle. Giant George would run around the room, and the only way to hurt Dirty Rat was to lure him into crashing into the villain.
He also appears in the second season of the show and menaces Sparx while she is trapped in the game.